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  "Title": "Detect Runs of Homozygosity and Runs of Heterozygosity in\nDiploid Genomes",
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  "Description": "Detection of runs of homozygosity and of heterozygosity in\ndiploid genomes using two methods: sliding windows (Purcell et\nal (2007) <doi:10.1086/519795>) and consecutive runs (Marras et\nal (2015) <doi:10.1111/age.12259>).",
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    "Froh_inbreeding",
    "Froh_inbreedingClass",
    "plot_DistributionRuns",
    "plot_InbreedingChr",
    "plot_manhattanRuns",
    "plot_PatternRuns",
    "plot_Runs",
    "plot_SnpsInRuns",
    "plot_StackedRuns",
    "plot_ViolinRuns",
    "readExternalRuns",
    "reorderDF",
    "slidingRUNS.run",
    "summaryRuns",
    "tableRuns"
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    {
      "page": "classifyRuns",
      "title": "Classify runs in bins.",
      "topics": [
        "classifyRuns"
      ]
    },
    {
      "page": "consecutiveRUNS.run",
      "title": "Main function to detect genomic RUNS (ROHom/ROHet) using the consecutive method",
      "topics": [
        "consecutiveRUNS.run"
      ]
    },
    {
      "page": "consecutiveRunsCpp",
      "title": "Function to detect consecutive runs in a vector (individual's genotypes)",
      "topics": [
        "consecutiveRunsCpp"
      ]
    },
    {
      "page": "createRUNdf",
      "title": "Function to create a dataframe of RUNS per individual animal Requires a map file (other filename to read or R object) Parameters on maximum number of missing and opposite genotypes in the run (not the window) are implemented here",
      "topics": [
        "createRUNdf"
      ]
    },
    {
      "page": "findOppositeAndMissing",
      "title": "Function to calculate oppositeAndMissingGenotypes array",
      "topics": [
        "findOppositeAndMissing"
      ]
    },
    {
      "page": "Froh_inbreeding",
      "title": "Function to calculated Froh genome-wide or chromosome-wide",
      "topics": [
        "Froh_inbreeding"
      ]
    },
    {
      "page": "Froh_inbreedingClass",
      "title": "Function to calculated Froh using a ROH-class",
      "topics": [
        "Froh_inbreedingClass"
      ]
    },
    {
      "page": "genoConvertCpp",
      "title": "Convert 0/1/2 genotypes to 0/1",
      "topics": [
        "genoConvertCpp"
      ]
    },
    {
      "page": "heteroZygotTest",
      "title": "Function to check whether a window is (loosely) heterozygous or not",
      "topics": [
        "heteroZygotTest"
      ]
    },
    {
      "page": "heteroZygotTestCpp",
      "title": "Function to check whether a window is (loosely) heterozygous or not",
      "topics": [
        "heteroZygotTestCpp"
      ]
    },
    {
      "page": "homoZygotTest",
      "title": "Function to check whether a window is (loosely) homozygous or not",
      "topics": [
        "homoZygotTest"
      ]
    },
    {
      "page": "homoZygotTestCpp",
      "title": "Function to check whether a window is (loosely) homozygous or not",
      "topics": [
        "homoZygotTestCpp"
      ]
    },
    {
      "page": "pedConvertCpp",
      "title": "Convert ped genotypes to 0/1",
      "topics": [
        "pedConvertCpp"
      ]
    },
    {
      "page": "plot_DistributionRuns",
      "title": "Plot Distribution of runs",
      "topics": [
        "plot_DistributionRuns"
      ]
    },
    {
      "page": "plot_InbreedingChr",
      "title": "Plot Froh-based inbreeding coefficients by group",
      "topics": [
        "plot_InbreedingChr"
      ]
    },
    {
      "page": "plot_manhattanRuns",
      "title": "Plot the proportion of times SNPs are inside runs - MANHATTAN PLOT",
      "topics": [
        "plot_manhattanRuns"
      ]
    },
    {
      "page": "plot_PatternRuns",
      "title": "Plot sum of run-lengths (or average run-lengths) against the number of runs per individual",
      "topics": [
        "plot_PatternRuns"
      ]
    },
    {
      "page": "plot_Runs",
      "title": "Function to plot runs per individual",
      "topics": [
        "plot_Runs"
      ]
    },
    {
      "page": "plot_SnpsInRuns",
      "title": "Plot the number of times each SNP falls inside runs",
      "topics": [
        "plot_SnpsInRuns"
      ]
    },
    {
      "page": "plot_StackedRuns",
      "title": "Plot stacked runs",
      "topics": [
        "plot_StackedRuns"
      ]
    },
    {
      "page": "plot_ViolinRuns",
      "title": "Violin plot of run length per individual (either sum or mean)",
      "topics": [
        "plot_ViolinRuns"
      ]
    },
    {
      "page": "readExternalRuns",
      "title": "Read runs from external files",
      "topics": [
        "readExternalRuns"
      ]
    },
    {
      "page": "readPOPCpp",
      "title": "Function to return a dataframe of population (POP, ID)",
      "topics": [
        "readPOPCpp"
      ]
    },
    {
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      "title": "Function to reorder data frames by CHROMOSOME",
      "topics": [
        "reorderDF"
      ]
    },
    {
      "page": "slidingRUNS.run",
      "title": "Main function to detect RUNS (ROHom/ROHet) using sliding windows (a la Plink)",
      "topics": [
        "slidingRUNS.run"
      ]
    },
    {
      "page": "slidingWindow",
      "title": "Function to slide a window over a vector (individual's genotypes)",
      "topics": [
        "slidingWindow"
      ]
    },
    {
      "page": "slidingWindowCpp",
      "title": "Function to slide a window over a vector (individual's genotypes)",
      "topics": [
        "slidingWindowCpp"
      ]
    },
    {
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      "title": "Function to return a vector of T/F for whether a SNP is or not in a RUN",
      "topics": [
        "snpInRun"
      ]
    },
    {
      "page": "snpInRunCpp",
      "title": "Function to return a vector of T/F for whether a SNP is or not in a RUN",
      "topics": [
        "snpInRunCpp"
      ]
    },
    {
      "page": "snpInsideRunsCpp",
      "title": "Function to count number of times a SNP is in a RUN",
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    },
    {
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      "title": "Function to retrieve most common runs in the population",
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      ]
    },
    {
      "page": "writeRUN",
      "title": "Function to write out RUNS per individual animal",
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      ]
    }
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      "source": "detectRUNS.vignette.Rmd",
      "filename": "detectRUNS.vignette.html",
      "title": "detectRUNS: an R package to detect runs of homozygosity and heterozygosity in diploid genomes",
      "author": "Filippo Biscarini, Paolo Cozzi, Giustino Gaspa, Gabriele Marras",
      "engine": "knitr::rmarkdown",
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        "Sample data",
        "Detect runs",
        "sliding-window-based run detection",
        "consecutive SNP-based run detection",
        "\"Runs of heterozygosity\" (a.k.a. heterozygosity-rich regions)",
        "Summary statistics on detected runs",
        "Plots",
        "$F_{ROH}$: ROH-based inbreeding",
        "Importing data from external files",
        "References"
      ],
      "created": "2017-11-08 08:32:49",
      "modified": "2026-05-28 16:27:15",
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